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KMID : 1137820090300050355
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의공학회지
2009 Volume.30 No. 5 p.355 ~ p.361
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Mitochondria Medicine and its Research Trend
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Shim Eun-Bo
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Abstract
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Mitochondria play a key role in maintaining life by producing ATP and heat. Recent researches have demonstrated that degenerative diseases such as heart failure, obesity/diabetes, cardiovascular disease, and psychiatric diseases are accompanied by mitochondria dysfunction. In this sense, mitochondria medicine considers the significance of mitochondria in human pathology and tries to explain degenerative diseases as a fatal consequence of mitochondria dysfunction. Here, I introduce the fundamentals of mitochondria physiology and present examples showing the relationship between mitochondria dysfunction and chronic complex diseases. Although mitochondria medicine uses a molecular biological approach predominantly, a biomedical engineering approach might play a critical role in unveiling the complexity of mitochondria medicine and in its application to the diagnosis and treatment of chronic diseases. Thus, I also briefly review the prospects of research using biomedical engineering methods.
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KEYWORD
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Mitochondria medicine, Electron transfer chain, ROS hypothesis for aging, Mitochondria dysfunction
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